Key result
Serum IGFBP-2 levels were significantly lower in obese (5.78 ng/mL) and overweight (6.56 ng/mL) children compared to normal BMI controls (11.31 ng/mL) and negatively correlated with insulin resistance.
Cross-Sectional (n=134)
Yes
Absolute Event Rate: 5.78% vs 11.31%
p-value: p=<0.01
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Lower IGFBP-2 may signal insulin resistance in obese children; hypothesis-generating for cardiovascular risk stratification and requires prospective validation.
Ko et al. (2012) conducted a cross-sectional in Obesity and Overweight (n=134). Obesity vs. Normal BMI was evaluated on Serum IGFBP-2 levels (ng/mL) (p=<0.01). Serum IGFBP-2 levels were significantly lower in obese (5.78 ng/mL) and overweight (6.56 ng/mL) children compared to normal BMI controls (11.31 ng/mL) and negatively correlated with insulin resistance.
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