Key result
Review maps how adenylyl cyclase isoforms and A-kinase anchoring proteins interact to regulate cardiac function.
This review highlights the importance of adenylyl cyclase isoforms and their interaction with A-kinase anchoring proteins in regulating cardiac physiology and stress response pathways.
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways. Local pools of cAMP are maintained by macromolecular complexes formed by A-kinase anchoring proteins (AKAPs). AKAPs facilitate control by bringing together regulators of the cAMP pathway including G-protein-coupled receptors, ACs, and downstream effectors of cAMP to finely tune signaling. This review will summarize the distinct roles of AC isoforms in cardiac function and how interactions with AKAPs facilitate AC function, highlighting newly appreciated roles for lesser abundant AC isoforms.
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Baldwin et al. (2018) conducted a review in Cardiac physiology. Adenylyl cyclase (AC) isoforms and AKAPs was evaluated. This review summarizes the distinct roles of adenylyl cyclase isoforms in cardiac function and how interactions with A-kinase anchoring proteins facilitate their signaling.
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