Key result
The interaction of A kinase-anchoring proteins with distinct adenylyl cyclase isoforms plays a key role in regulating cardiovascular physiology and the pathophysiology of heart failure.
This review highlights the importance of A kinase-anchoring proteins in localizing cAMP signaling and their impact on cardiovascular physiology and heart failure pathophysiology.
3'-5'-Cyclic adenosine monophosphate (cAMP), generated by adenylyl cyclase (AC), serves as a second messenger in signaling pathways regulating many aspects of cardiac physiology, including contraction rate and action potential duration, and in the pathophysiology of hypertrophy and heart failure. A kinase-anchoring proteins localize the effect of cAMP in space and time by organizing receptors, AC, protein kinase A, and other components of the cAMP cascade into multiprotein complexes. In this review, we discuss how the interaction of A kinase-anchoring proteins with distinct AC isoforms affects cardiovascular physiology.
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Efendiev et al. (2011) conducted a review in Cardiovascular physiology and pathology. Interaction of A kinase-anchoring proteins with distinct adenylyl cyclase isoforms was evaluated. The interaction of A kinase-anchoring proteins with distinct adenylyl cyclase isoforms plays a key role in regulating cardiovascular physiology and the pathophysiology of heart failure.
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