Key result
Compartmentation of cyclic nucleotide signaling via scaffolding proteins like AKAPs is essential for the precise spatial-temporal control of PKA- and PKG-mediated phosphorylation in the heart.
Population
Cardiac cells (basic science review of cyclic nucleotide signaling)
Design
Review
Authors
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May blunt efficacy of global cyclic nucleotide elevation in cardiac disease; leaves open AKAP-targeted interventions pending validation.
Highlights the critical role of scaffolding proteins like AKAPs in the spatial-temporal compartmentation of cyclic nucleotide signaling in cardiac cells.
Dodge‐Kafka et al. (2006) conducted a review in Cardiac function and cyclic nucleotide signaling. Compartmentation of cyclic nucleotide signaling via scaffolding proteins like AKAPs is essential for the precise spatial-temporal control of PKA- and PKG-mediated phosphorylation in the heart.
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