Key result
Updated SPRINT analyses address the validity and generalizability of the original 2015 findings.
Why the study?
The SPRINT results influenced practice but generated discussion regarding validity, generalizability, and importance; additional analyses have addressed these concerns.
This article reviews and responds to key questions regarding the validity, generalizability, and importance of the SPRINT trial results.
Answers are grounded in this paper and cite their sources.
Addresses SPRINT validity concerns; leaves open broader generalizability and implementation questions.
The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT primary results manuscript in 2015, additional results and analyses of the data have addressed these concerns. The primary objective of this article is to respond to key questions that have been raised.
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Wright et al. (2021) conducted a review in Hypertension. Systolic Blood Pressure Intervention Trial (SPRINT) was evaluated. Updated analyses of the Systolic Blood Pressure Intervention Trial (SPRINT) address key questions regarding the validity, generalizability, and clinical importance of the original 2015 findings.
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