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October 19, 2016FEBS Journal

Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

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Authors

RSRalph D. SandersonMEMichael ElkinARAlan C. Rapraeger

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Overview

Review highlights heparanase's role in cancer and inflammation, indicating potential therapeutic targets.

Key Points

  • The aim is to explore how heparanase influences cancer, autophagy, and inflammation through various mechanisms.
  • Review of recent clinical trials and developments in heparanase research.
  • Analysis of heparanase's impact on exosomes and autophagy.
  • Discussion of heparanase inhibitors and their therapeutic potential.
  • Heparanase influences gene expression and cell behavior through heparin-binding growth factors.
  • Clinical trials show early efficacy of heparanase inhibitors in cancer treatment.
  • Heparanase regulates tumor metastasis, angiogenesis, and chemoresistance through novel mechanisms.

Cite This Study

Sanderson et al. (2016) studied this question.

synapsesocial.com/papers/6a06f9782edded7c7b8420dfhttps://doi.org/10.1111/febs.13932
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis2001 · 602 citations
  2. 2Heparan Sulfate Proteoglycans (HSPGs) and Their Degradation in Health and Disease2025
  3. 3The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives2025 · 7 citations
  4. 4Classification and Molecular Functions of Heparan Sulfate Proteoglycans and Their Molecular Mechanisms with the Receptor2024 · 14 citations
  5. 5Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study2024 · 8 citations