Key result
Intravenous cannulation during head-up tilt testing induced symptomatic hypotension in 50% of healthy elderly subjects, compared to 0% when non-cannulated.
Why the study?
Does intravenous cannulation alter the response to head-up tilt testing in healthy elderly subjects?
Observational (n=10)
Does intravenous cannulation alter the response to head-up tilt testing in healthy elderly subjects?
Intravenous cannulation alone can induce false-positive responses (symptomatic hypotension) during head-up tilt testing in healthy elderly subjects, suggesting caution when interpreting positive responses with intravenous isoprenaline.
Answers are grounded in this paper and cite their sources.
May confound tilt test specificity in elderly patients; leaves open validation of non-cannulated protocols.
Prolonged head-up tilt is increasingly used as a diagnostic test for vasovagal syncope. Its sensitivity is reported to increase with the concurrent administration of intravenous isoprenaline. False-positive responses are common in young controls particularly following intravascular instrumentation. We studied the influence of intravenous cannulation alone on responses to head-up tilt in ten healthy elderly subjects. All remained asymptomatic during tilt when non-cannulated whilst five developed symptomatic hypotension following cannulation. Thus, intravascular instrumentation influences responses to held-up tilt in elderly subjects; the significance of positive responses obtained using intravenous isoprenaline in this age group requires further evaluation.
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McIntosh et al. (1994) conducted an observational in Vasovagal syncope (n=10). Intravenous cannulation vs. Non-cannulated was evaluated on Symptomatic hypotension during head-up tilt. Intravenous cannulation during head-up tilt testing induced symptomatic hypotension in 50% of healthy elderly subjects, compared to 0% when non-cannulated.
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