Key result
TRPV1 and TRPM4 channels mediate heat-induced arterial tone to protect capillaries against blood fluidity changes.
Thermosensitive myogenic tone, mediated by TRPV1 and TRPM4 channels, is a fundamental homeostatic mechanism that regulates tissue perfusion and protects capillary integrity.
May guide studies of vascular tone in fever or heat stress; leaves open translation to human capillary protection.
) of ~11 to 20. Each of these tissues has a distinct resting temperature, and we find that arterial thermosensitivity is tuned to this temperature, making myogenic tone sensitive to small thermal fluctuations. Interestingly, temperature and intraluminal pressure are sensed largely independently and the signals integrated to trigger myogenic tone. We demonstrate that thermosensitive channels TRPV1 and TRPM4 mediate heat-induced tone in skeletal muscle arteries with discrete temperature sensitivities. Similarly, TRPM4 contributes to heat-induced tone in gut and brain arteries. The half-maximal responses occur at approximately 31 °C for TRPV1 and 33 °C for TRPM4. Variations in tissue temperature are known to alter blood fluidity and therefore vascular conductance; remarkably, thermosensitive tone counterbalances this effect, thus protecting capillary integrity and fluid balance. In conclusion, thermosensitive myogenic tone is a fundamental homeostatic mechanism regulating tissue perfusion.
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Phan et al. (2025) studied Physiological arterial thermosensitivity. Thermosensitive channels TRPV1 and TRPM4 mediate heat-induced myogenic tone in arteries, counterbalancing temperature-induced changes in blood fluidity to protect capillary integrity.
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