Key result
Non-noxious cooling of the skin increased the blood oxygen level-dependent signal in the human rostral medullary raphe by 3.9% compared to noncooling periods.
Observational (n=10)
No
p-value: p=<0.01
Human rostral medullary raphé neurons are selectively activated in response to a thermoregulatory challenge, identifying homologous thermoregulatory neurons to those in rodents.
Authors
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Does not guide clinical practice; extends rodent thermoregulatory findings to human medullary raphe.
McAllen et al. (2006) conducted an observational in Healthy volunteers (n=10). Skin cooling via water-perfused body suit vs. Noncooling periods (thermoneutral baseline and rewarming at 31-33°C) was evaluated on Change in blood oxygen level-dependent (BOLD) signal in the rostral medullary raphe (p=<0.01). Non-noxious cooling of the skin increased the blood oxygen level-dependent signal in the human rostral medullary raphe by 3.9% compared to noncooling periods.
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