Key result
Cold stimuli in the tail significantly increased firing frequency in 59% of NRO neurons, while warm stimuli inhibited 48% of neurons, suggesting their involvement in thermoregulation.
Population
Anesthetized rats
Comparison
Cold and warm stimuli applied to the tail vs Baseline firing rate before stimulation
Design
Preclinical
Authors
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NRO thermoresponsiveness in rodents leaves open translation to human thermoregulation or vascular control; hypothesis-generating for brainstem circuits.
Nucleus raphe obscurus neurons exhibit opposite responses to cooling and heating, suggesting their involvement in homoeothermic vascular adaptations secondary to changes in cutaneous temperature.
Ulhôa et al. (2013) studied Thermoregulation. Cold and warm stimuli in the tail vs. Baseline (before stimulation) was evaluated on Firing rate of NRO neurons. Cold stimuli in the tail significantly increased firing frequency in 59% of NRO neurons, while warm stimuli inhibited 48% of neurons, suggesting their involvement in thermoregulation.
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