The Impact of DNMT3A Status on NPM1 MRD Predictive Value and Survival in Elderly AML Patients Treated Intensively

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DNMT3A mutation status impacts the predictive value of NPM1 measurable residual disease (MRD) and survival, identifying a specific subgroup of intensively treated elderly AML patients at high risk of relapse. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Maël Heiblig; Nicolas Duployez; Alice Marceau‐Renaut; Delphine Lebon; Laure Goursaud; Isabelle Plantier; Laure Stalnikiewich; Nathalie Cambier; Marie Balsat; Gaëlle Fossard; Hélène Labussière‐Wallet; Fiorenza Barraco; Sophie Ducastelle-Leprêtre; Pierre Sujobert; Sarah Huet; Sandrine Hayette; Hervé Ghesquières; Xavier Thomas; Claude Preudhomme

doi:10.3390/cancers13092156

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also identifies a subgroup of patients at high risk of relapse.

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Heiblig et al. (2021) studied this question.

synapsesocial.com/papers/6a074d54d9167a9c2a585688 https://doi.org/10.3390/cancers13092156

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The Impact of DNMT3A Status on NPM1 MRD Predictive Value and Survival in Elderly AML Patients Treated Intensively

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The Impact of DNMT3A Status on NPM1 MRD Predictive Value and Survival in Elderly AML Patients Treated Intensively

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