Key result
In ovine hearts, subepicardial radial wall thickening increased significantly from week 1 to week 8 after marker implantation, driven by subepicardial sheet extension and sheet-normal shear.
The study proposes a mechanistic model suggesting that a selective decrease in subepicardial intercellular matrix stiffness is responsible for the elimination of the transmural wall thickening gradient 1-8 weeks after marker implantation surgery in ovine hearts.
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Ovine findings do not inform clinical practice; leaves open whether matrix stiffness modulates human transmural wall mechanics.
Cheng et al. (2005) studied Left ventricular mechanics (n=7). Surgical implantation of transmural radiopaque beads was evaluated on Transmural sheet strains and wall thickening. In ovine hearts, subepicardial radial wall thickening increased significantly from week 1 to week 8 after marker implantation, driven by subepicardial sheet extension and sheet-normal shear.
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