Key result
Systolic wall thickening in the anterior basal region was 1.6 to 1.9 times that in the lateral equatorial region despite identical systolic fiber shortening, driven by different laminar mechanisms.
Population
Nine sheep with transmural radiopaque markers inserted into the anterior basal and lateral equatorial left…
Comparison
Measurement of 4-dimensional marker dynamics… vs Comparison between anterior basal and lateral…
Design
Preclinical
Authors
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Regional sheet dynamics may drive LV thickening beyond fiber shortening; hypothesis-generating for cell therapy and remodeling strategies.
Systolic left ventricular wall thickening depends heavily on regional sheet dynamics and orientations rather than just fiber shortening, which has important implications for cell therapy and surgical ventricular remodeling.
Cheng et al. (2008) studied Left ventricular wall thickening mechanisms (n=9). Transmural radiopaque markers and 4D marker dynamics vs. Anterior basal versus lateral equatorial LV regions was evaluated on Regional variability and transmural distribution of laminar extension, thickening, and shear. Systolic wall thickening in the anterior basal region was 1.6 to 1.9 times that in the lateral equatorial region despite identical systolic fiber shortening, driven by different laminar mechanisms.
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