Key result
High D-glucose exposure in endothelial cells suppressed mitochondrial nitric oxide production and enhanced superoxide generation, which was restored by a superoxide dismutase mimetic.
Why the study?
Does a hyperglycemic environment alter mitochondrial nitric oxide and superoxide production in endothelial cells?
Does a hyperglycemic environment alter mitochondrial nitric oxide and superoxide production in endothelial cells?
Hyperglycemia induces an 'uncoupled' state of mitochondrial NOS in endothelial cells, shifting its function from nitric oxide production to superoxide generation.
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Should not change clinical practice; hypothesis-generating for mitochondrial NOS uncoupling in diabetic endothelial dysfunction.
Brodsky et al. (2002) studied Hyperglycemia. High concentration of D-glucose vs. L-glucose or control medium was evaluated on Mitochondrial NO production and superoxide generation. High D-glucose exposure in endothelial cells suppressed mitochondrial nitric oxide production and enhanced superoxide generation, which was restored by a superoxide dismutase mimetic.
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