Population
cultured retinal microvascular endothelial cells (RMECs)
Comparison
exposure to high ambient glucose and exogenous… vs cultured in 5 mmol/l glucose
Design
Preclinical
Follow-up
5 days
Authors
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May not alter clinical practice; leaves open whether eNOS suppression drives diabetic retinopathy in vivo.
High glucose and advanced glycation end products suppress constitutive nitric oxide synthase expression in retinal vascular endothelial cells, suggesting a mechanism for diabetic vascular endothelial dysfunction.
Chakravarthy et al. (1998) studied this question.
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