Skeletal muscle mass loss and elevated insulin resistance act synergistically to increase heart failure risk in older adults, particularly those with low-decrease ASMI and high-decrease eGDR (P<0.001).
Cohort (n=11,596)
Does the combination of skeletal muscle mass loss and elevated insulin resistance increase heart failure risk in older adults?
Skeletal muscle mass loss and elevated insulin resistance act synergistically to increase the risk of heart failure in older adults.
p-value: p=< 0.001
BACKGROUND: Skeletal muscle mass loss and insulin resistance (IR) are associated with cardiovascular diseases risk. However, it remains unclear whether the combination of skeletal muscle mass loss and elevated IR affects heart failure (HF) risk. Here, we investigate the association between a combination of appendicular skeletal muscle mass index (ASMI) with estimated glucose disposal rate (eGDR) and HF risk in older adults. METHODS: A prospective analysis and a dual-trajectory analysis were carried out to investigate the association of the combined effect of ASMI and eGDR with HF risk. A total of 11,596 adults aged ≥ 60 years were enrolled from the community for prospective analysis. Among them, 10,489 were eligible for the dual-trajectory analysis. The temporal evolution of ASMI and eGDR was determined using a dual-trajectory model. RESULTS: < 0.001) in group 3 with low-decrease ASMI and high-decrease eGDR. CONCLUSIONS: Skeletal muscle mass loss and elevated IR act synergistically to increase the HF risk in older adults. Comprehensive management of muscle mass and IR might be a useful and effective strategy for preventing and controlling HF. TRIAL REGISTRATION: Retrospectively registered number ChiCTREOC17013598.
Liu et al. (Wed,) conducted a cohort in Heart failure (n=11,596). Skeletal muscle mass loss and elevated insulin resistance (ASMI and eGDR trajectories) was evaluated on Heart failure risk (p=< 0.001). Skeletal muscle mass loss and elevated insulin resistance act synergistically to increase heart failure risk in older adults, particularly those with low-decrease ASMI and high-decrease eGDR (P<0.001).