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Inactivation of the Rb1 pathway leads to mTor overexpression and constitutive Akt-473 phosphorylation, resulting in resistance to anoikis and a block in c-Raf/Erk activation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 25, 2009Molecular and Cellular BiologyOpen Access

Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis, and a Block in c-Raf Activation

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SEShahenda El‐NaggarChildren Cancer Hospital YLYongqing LiuSouthern University of Science and Technology DDDouglas C. DeanUniversity of Wisconsin–Madison

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Cite This Study

El‐Naggar et al. (2009) studied this question.

synapsesocial.com/papers/6a0788ce3d01ce3fbe8b37f2 https://doi.org/10.1128/mcb.00197-09

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August 25, 2009Molecular and Cellular BiologyOpen Access

Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis, and a Block in c-Raf Activation

View Full Paper

Ask AI

Bookmark

Authors

SEShahenda El‐NaggarChildren Cancer Hospital YLYongqing LiuSouthern University of Science and Technology DDDouglas C. DeanUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

El‐Naggar et al. (2009) studied this question.

synapsesocial.com/papers/6a0788ce3d01ce3fbe8b37f2 https://doi.org/10.1128/mcb.00197-09

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