Key result
Overexpression of Gsalpha in the hearts of transgenic mice induces apoptosis of cardiac myocytes, with approximately 0.6% of myocyte nuclei containing fragmented DNA in older animals.
Population
15- to 18-month-old Gsalpha transgenic mice and cultured neonatal cardiac myocytes from Gsalpha transgenic…
Comparison
Overexpression of the Gs alpha subunit… vs Wild-type controls
Design
Preclinical
Authors
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May implicate Gsα in age-related cardiomyopathy; hypothesis-generating, requires human validation.
Enhanced activation of beta-adrenergic signaling by overexpression of Gsalpha induces apoptosis of cardiac myocytes, representing a potential mechanism for the development of cardiomyopathy.
Geng et al. (1999) studied Cardiomyopathy. Gsalpha overexpression vs. Wild-type controls was evaluated on Myocyte apoptosis (TUNEL staining and internucleosomal DNA fragmentation). Overexpression of Gsalpha in the hearts of transgenic mice induces apoptosis of cardiac myocytes, with approximately 0.6% of myocyte nuclei containing fragmented DNA in older animals.
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