Key result
Automated analysis using CASCADE provided accurate measurements of carotid atherosclerotic burden compared with manual outlining (Pearson correlation 0.94 for maximal normalized wall index).
Why the study?
Does automated analysis using CASCADE provide accurate measurements of carotid atherosclerotic burden and composition compared with manual outlining in subjects with carotid artery stenosis?
Observational (n=26)
Does automated analysis using CASCADE provide accurate measurements of carotid atherosclerotic burden and composition compared with manual outlining in subjects with carotid artery stenosis?
Effect estimate: Pearson correlation 0.94 for NWI
Automated analysis using CASCADE provides accurate and reproducible measurements of carotid atherosclerotic burden and composition on MRI compared with manual outlining.
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May support efficient automated carotid plaque quantification on MRI; leaves open prospective validation before clinical use.
Kerwin et al. (2007) conducted an observational in Carotid artery stenosis (n=26). Computer-Aided System for CArdiovascular Disease Evaluation (CASCADE) vs. Manual outlining was evaluated on Agreement between manual and automated reviews for maximal normalized wall index (NWI), maximal wall thickness (WT), necrotic core (NC), and calcified (CA) areas (Pearson correlation 0.94 for NWI). Automated analysis using CASCADE provided accurate measurements of carotid atherosclerotic burden compared with manual outlining (Pearson correlation 0.94 for maximal normalized wall index).
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