What question did this study set out to answer?

This study aims to evaluate the comparability of mean wall thickness measured by MRI to intima-media thickness measured by ultrasound in carotid arteries.

June 19, 2006Journal of Magnetic Resonance ImagingOpen Access

Automated measurement of mean wall thickness in the common carotid artery by MRI: A comparison to intima‐media thickness by B‐mode ultrasound

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Carotid artery stenosis (n=43). Intervention: Automated measurement of mean wall thickness (MWT) by MRI vs. Intima-media thickness (IMT) by B-mode ultrasound. Primary outcome: Correlation between MWT and IMT measurements (r = 0.93, p=<0.001).

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Key result

Automated measurement of mean wall thickness by MRI was highly correlated with intima-media thickness by B-mode ultrasound (r = 0.93; P < 0.001).

Why the study?

Does automated measurement of mean wall thickness by MRI correlate with intima-media thickness by B-mode ultrasound in patients with carotid stenosis?

Population

43 patients with 16-79% stenosis by duplex US, yielding 28 carotid arteries with sufficient proximal…

Comparison

Automated measurement of mean wall thickness of… vs Intima-media thickness measurement by B-mode…

Design

Cross-sectional

Authors

HUHunter R. UnderhillCardiac Imaging WKWilliam KerwinWorcester Polytechnic Institute THThomas S. HatsukamiVascular Medicine

Discussion

Member takes

Implication

Supports automated MRI carotid assessment in research; leaves open whether it improves risk prediction over ultrasound IMT.

Key Points

This study aims to evaluate the comparability of mean wall thickness measured by MRI to intima-media thickness measured by ultrasound in carotid arteries.
Part of the two-year ORION trial with 43 patients having 16-79% stenosis by duplex ultrasound.
Used high-resolution MRI and B-mode ultrasound to measure carotid arteries' parameters.
Developed an automated algorithm for MWT measurement, assessing reproducibility using root-mean-square difference.
Mean wall thickness (MWT) and intima-media thickness (IMT) showed a high Pearson correlation coefficient of r = 0.93; P < 0.001.
The RMS difference between readers was 0.01 mm, and interscan RMS difference was 0.04 mm.
The automated algorithm achieved 100% correct identification of lumen in 28 cases and 93% for outer-wall boundary.

Study Design

Type

Observational (n=43)

Structured PICO

Does automated measurement of mean wall thickness by MRI correlate with intima-media thickness by B-mode ultrasound in patients with carotid stenosis?

Population

43 patients with 16-79% stenosis by duplex US (part of the ORION trial), yielding 28 carotid arteries with sufficient proximal coverage and adequate image quality on both MRI and US.

Intervention

Automated measurement of mean wall thickness (MWT) of the common carotid artery by high-resolution MRI using a novel algorithm utilizing statistical shape modeling.

Comparator

Intima-media thickness (IMT) measurement by B-mode ultrasound.

Outcome

Correlation between MWT by MRI and IMT by B-mode US.surrogate

Main Result

Effect estimate: r = 0.93

p-value: p=<0.001

Automated MRI measurements of common carotid artery mean wall thickness are highly reproducible and correlate strongly with ultrasound intima-media thickness, an established marker of cardiovascular risk.

Cite This Study

Underhill et al. (2006) conducted an observational in Carotid artery stenosis (n=43). Automated measurement of mean wall thickness (MWT) by MRI vs. Intima-media thickness (IMT) by B-mode ultrasound was evaluated on Correlation between MWT and IMT measurements (r = 0.93, p=<0.001). Automated measurement of mean wall thickness by MRI was highly correlated with intima-media thickness by B-mode ultrasound (r = 0.93; P < 0.001).

synapsesocial.com/papers/6a07893cc9983f2ec4c64091 https://doi.org/10.1002/jmri.20636

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Automated measurement of mean wall thickness in the common carotid artery by MRI: A comparison to intima‐media thickness by B‐mode ultrasound

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Automated measurement of mean wall thickness in the common carotid artery by MRI: A comparison to intima‐media thickness by B‐mode ultrasound

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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