Key result
In vivo MRI quantification of carotid plaque composition was statistically equivalent to histology for lipid-rich/necrotic core (23.7% vs 20.3%; P=0.1), loose matrix, and dense fibrous tissue.
Why the study?
Does in vivo MRI accurately quantify carotid atherosclerotic plaque components compared to histology in subjects scheduled for carotid endarterectomy?
Population
31 subjects scheduled for carotid endarterectomy
Comparison
In vivo MRI imaging with a 1.5T scanner using… vs Histology sections matched to corresponding MR…
Design
Cross-sectional
Authors
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Supports noninvasive MRI for carotid plaque quantification except calcification; leaves open clinical adoption pending prospective validation.
Observational (n=31)
Does in vivo MRI accurately quantify carotid atherosclerotic plaque components compared to histology in subjects scheduled for carotid endarterectomy?
Absolute Event Rate: 23.7% vs 20.3%
p-value: p=0.1
In vivo MRI accurately and reproducibly quantifies major carotid atherosclerotic plaque components, with the exception of calcification, when compared to histology.
Saam et al. (2004) conducted an observational in Carotid atherosclerotic plaque (n=31). In vivo MRI vs. Histology was evaluated on Area measurement of lipid-rich/necrotic core (LR/NC) as a percentage of total wall area (p=0.1). In vivo MRI quantification of carotid plaque composition was statistically equivalent to histology for lipid-rich/necrotic core (23.7% vs 20.3%; P=0.1), loose matrix, and dense fibrous tissue.
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