Key result
Simulated in vivo carotid MRI demonstrated high correlation with histological ground truth for measuring luminal, vessel wall, and lipid-rich necrotic core areas (R ≥ 0.95), but underestimated LRNC area by 24%.
Why the study?
Can clinical carotid MRI accurately quantify atherosclerotic plaque components such as the thin fibrous cap and lipid-rich necrotic core?
Population
Simulated images of cross-sectional carotid plaque geometries derived from histological data of 12 patients
Comparison
Segmentation of simulated in vivo carotid MRI by… vs Submillimeter scale ground truth from…
Design
Other
Authors
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Supports carotid MRI for research plaque quantification; leaves open clinical use for LRNC assessment given 24% underestimation.
Can clinical carotid MRI accurately quantify atherosclerotic plaque components such as the thin fibrous cap and lipid-rich necrotic core?
Effect estimate: R = 0.996, ICC = 0.99 for luminal area
Current clinical MRI can accurately quantify carotid plaque luminal and LRNC areas but has limitations in quantifying thin fibrous cap thickness, which may affect rupture risk assessment.
Nieuwstadt et al. (2013) studied Atherosclerotic carotid plaques (n=12). Simulated in vivo carotid MRI vs. Histological ground truth was evaluated on Correlation (R) and intraclass correlation (ICC) in measuring luminal area, vessel wall area, and LRNC area (R = 0.996, ICC = 0.99 for luminal area). Simulated in vivo carotid MRI demonstrated high correlation with histological ground truth for measuring luminal, vessel wall, and lipid-rich necrotic core areas (R ≥ 0.95), but underestimated LRNC area by 24%.
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