What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiac device infections (permanent pacemaker and implantable cardioverter-defibrillator) (n=189). Intervention: Complete device removal and antibiotic administration. Primary outcome: Cure of infection.

What question did this study set out to answer?

The aim is to describe the management strategies and outcomes for patients with infections related to pacemakers and implantable cardioverter-defibrillators.

May 15, 2026Journal of the American College of Cardiology

Management and Outcome of Permanent Pacemaker and Implantable Cardioverter-Defibrillator Infections

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Key result

Complete device removal and antibiotics achieve a 96% cure rate for pacemaker and ICD infections.

n=189

Why the study?

Infection is a serious complication of PPM and ICD implantation, but optimal care of patients with cardiac device infections is not well defined.

Does complete device removal combined with antibiotic therapy cure cardiac device infections in patients with permanent pacemakers or implantable cardioverter-defibrillators?

Key Points

The aim is to describe the management strategies and outcomes for patients with infections related to pacemakers and implantable cardioverter-defibrillators.
Retrospective review of patients with cardiac device infections admitted to Mayo Clinic Rochester from January 1, 1991, to December 31, 2003.
Data collected included demographic and clinical information, followed by descriptive analysis.
Infection management included device removal and tailored antibiotic therapy.
Out of 189 patients with infections, 96% achieved a cure after complete device removal and appropriate antibiotic treatment.
Common infections included generator pocket infection (69%) and device-related endocarditis (23%).
Median follow-up was 175 days post-discharge, with varying antibiotic durations based on infection type (e.g., 28 days for S. aureus).

Study Design

Type

Cohort (n=189)

Multicenter

Structured PICO

Does complete device removal combined with antibiotic therapy cure cardiac device infections in patients with permanent pacemakers or implantable cardioverter-defibrillators?

Population

189 patients with cardiac device infections (138 permanent pacemakers, 51 implantable cardioverter-defibrillators), median age 71.2 years, admitted to a tertiary care facility.

Intervention

Complete device removal combined with antibiotic administration (median duration 14-28 days depending on clinical presentation and causative organism).

Outcome

Cure of cardiac device infectionhard clinical

An aggressive approach of combined antimicrobial treatment and complete device removal achieves a high cure rate (96%) in patients with cardiac device infections.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May inform CDI management at experienced centers; leaves open optimal strategies for broader populations.

Cite This Study

Sohail et al. (2007) conducted a cohort in Cardiac device infections (permanent pacemaker and implantable cardioverter-defibrillator) (n=189). Complete device removal and antibiotic administration was evaluated on Cure of infection. Complete device removal combined with antibiotic administration achieved a 96% cure rate in patients with permanent pacemaker and implantable cardioverter-defibrillator infections.

synapsesocial.com/papers/6a078dc7d9ec3070f22dd5f3 https://doi.org/10.1016/j.jacc.2007.01.072

Topics

Cardiac device therapy Infective endocarditis

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Management and Outcome of Permanent Pacemaker and Implantable Cardioverter-Defibrillator Infections

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Management and Outcome of Permanent Pacemaker and Implantable Cardioverter-Defibrillator Infections

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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