January 2, 2026Proceedings of the National Academy of Sciences1 citationsOpen Access

Peripheral nerve injury reduces macrophage efferocytosis to facilitate neuropathic pain

VPVipul K. PandeyThe University of Texas MD Anderson Cancer Center TAT. AcharyaThe University of Texas MD Anderson Cancer Center KWKendal F. WillcoxThe University of Texas MD Anderson Cancer Center

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Abstract

was conditionally deleted from macrophages. Our findings identify cleavage of MERTK from macrophages at the injury site as a pivotal regulator of pronociceptive and tissue-damaging neuroimmune signaling after PNI.

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