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May 9, 2022BMC Medical GenomicsOpen Access

Integrated investigation of DNA methylation, gene expression and immune cell population revealed immune cell infiltration associated with atherosclerotic plaque formation

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Why the study?

Atherosclerosis causes significant morbidity and mortality worldwide, but the molecular mechanisms underlying its pathogenesis remain largely unknown.

Population

Atherosclerotic plaque and normal aortic tissue samples

Comparison

Atherosclerotic lesion tissues vs normal aortic tissues

Design

Integrated epigenetic and transcriptional analysis with RT-qPCR validation

Authors

YYYihong YinZXZhaohong XieDCDong Chen

Discussion

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Overview

Supports immune-targeted pathway exploration in atherosclerosis; hypothesis-generating and requires validation before clinical consideration.

Key Points

  • This study aims to understand the molecular mechanisms behind atherosclerotic plaque formation by examining DNA methylation and immune cell populations.
  • Integrated DNA methylation and gene expression analysis in atherosclerotic plaques
  • Immune cell classification based on gene expression patterns
  • RT-qPCR validation for ten dysregulated genes
  • Global DNA methylation profiles significantly differ between normal aortic and atherosclerotic tissues.
  • Large numbers of immune cells, especially macrophages, were enriched in atherosclerotic plaques and correlated with dysregulated genes.
  • Differentially expressed genes were associated with key pathways in plaque formation such as blood vessel remodeling and cell adhesion.

Cite This Study

Yin et al. (2022) studied this question.

synapsesocial.com/papers/6a079992f8ea14d3ccc644b9https://doi.org/10.1186/s12920-022-01259-z
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