June 20, 2003The Journal of PhysiologyOpen Access

Partial blockade of skeletal muscle somatosensory afferents attenuates baroreflex resetting during exercise in humans

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Why the study?

Does partial blockade of skeletal muscle afferents attenuate baroreflex resetting during exercise in humans?

Structured PICO

Does partial blockade of skeletal muscle afferents attenuate baroreflex resetting during exercise in humans?

Population

9 human subjects

Intervention

Partial blockade of skeletal muscle afferents with epidural anaesthesia during 7 minutes of dynamic cycling at 30% maximal work load and 3 minutes of static one-legged contraction at 25% maximal voluntary contraction

Comparator

Same exercise protocols before epidural anaesthesia (control)

Outcome

Carotid baroreflex function assessed by heart rate (HR) and mean arterial pressure (MAP) responses to rapid pulses of hyper- and hypotensive stimuli to the necksurrogate

Afferent input from skeletal muscle is required for complete resetting of the carotid baroreflex during exercise, primarily modifying blood pressure control rather than heart rate.

Discussion

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Implication

Should not alter exercise guidance in patients; leaves open translation of afferent mechanisms to clinical autonomic disorders.

Cite This Study

Smith et al. (2003) studied this question.

synapsesocial.com/papers/6a07b38644ff8ad339f69a02 https://doi.org/10.1113/jphysiol.2003.044925

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