Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure
Why the study?
Does exercise-induced muscle mechanoreflex control of reflex renal vasoconstriction differ between heart failure patients and controls?
Population
19 heart failure (HF) patients and 19 controls (n=38)
Comparison
Two exercise protocols: 1) low-level rhythmic… vs Controls undergoing the same exercise protocols
Design
Case-control
Authors
Discussion
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Member takes
Implication
May underlie exercise intolerance in HF; hypothesis-generating for mechanoreflex-targeted interventions.
Structured PICO
Does exercise-induced muscle mechanoreflex control of reflex renal vasoconstriction differ between heart failure patients and controls?
P
Population
19 heart failure (HF) patients and 19 controls (n=38)
I
Intervention
Two exercise protocols: 1) low-level rhythmic handgrip (mechanoreceptors and central command) and 2) involuntary biceps contractions (mechanoreceptors)
C
Comparator
Controls undergoing the same exercise protocols
O
Outcome
Peak renal cortical vascular resistance (RCVR) and change in RCVR during exercise protocolssurrogate
Reflex renal vasoconstriction is exaggerated in magnitude and duration during dynamic exercise in HF patients, driven by intact muscle mechanoreceptor sensitivity.
Cite This Study
Middlekauff et al. (2001) studied this question.