March 16, 1999Circulation
Detection of Adenoviral Genome in the Myocardium of Adult Patients With Idiopathic Left Ventricular Dysfunction
Key result
Adenoviral genomic DNA was detected in 12 of 94 (12.8%) adult patients with idiopathic left ventricular dysfunction compared to 0 of 14 controls.
Why the study?
Is adenoviral infection present in the myocardium of adult patients with idiopathic left ventricular dysfunction?
Population
94 adult patients with idiopathic left ventricular dysfunction and 14 control patients
Design
Case-control
Authors
Discussion
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Implication
Adenoviral detection in idiopathic LV dysfunction is hypothesis-generating; leaves open causality and does not support practice change.
Study Design
Type
Case-Control (n=108)
Structured PICO
Is adenoviral infection present in the myocardium of adult patients with idiopathic left ventricular dysfunction?
P
Population
94 adult patients with idiopathic left ventricular dysfunction and 14 control patients
C
Comparator
14 control patients (for viral prevalence) and adenovirus-negative patients (for immune cell comparisons)
O
Outcome
Frequency of detection of adenoviral DNA and enteroviral RNA in myocardial tissue samplessurrogate
Main Result
Absolute Event Rate: 12.8% vs 0%
Adenovirus infection is present in a subset of adults with idiopathic left ventricular dysfunction and is associated with a distinct, suppressed T-cell immune response.
Cite This Study
Pauschinger et al. (1999) conducted a case-control in Idiopathic left ventricular dysfunction (n=108). Adenovirus and enterovirus detection via nPCR vs. Control patients without left ventricular dysfunction was evaluated on Frequency of detection of adenoviral DNA and enteroviral RNA in myocardial tissue samples. Adenoviral genomic DNA was detected in 12 of 94 (12.8%) adult patients with idiopathic left ventricular dysfunction compared to 0 of 14 controls.