Key result
Spatial fibrosis heterogeneity increases arrhythmia induction probability, driven primarily by maximal local fibrosis levels.
Population
2D spatial computational model of cardiac tissue with fibrosis using the ten Tusscher and Panfilov model for…
Comparison
Heterogeneous distribution of diffuse fibrosis… vs Homogeneous distribution of diffuse fibrosis.
Design
Preclinical
Authors
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Does not yet alter clinical arrhythmia risk assessment; extends computational models but requires in vivo validation.
In a computational model, spatial heterogeneity of myocardial fibrosis significantly increases the probability of arrhythmia induction, driven primarily by the maximal local fibrosis level.
Kazbanov et al. (2016) studied Cardiac arrhythmias and myocardial fibrosis. Spatial heterogeneity of fibrosis (computational modeling) was evaluated on Arrhythmia induction probability and dynamics. Spatial heterogeneity of fibrosis increases the probability of arrhythmia induction, with the maximal local fibrosis level being the most important factor determining arrhythmia formation and dynamics.
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