Key result
Computer modelling demonstrated that diffuse fibrosis slows wave propagation, increases vulnerability to spiral wave formation, and suppresses restitution-induced transition to fibrillation.
Computer modeling suggests that in the presence of large amounts of diffuse fibrotic tissue, mechanisms other than restitution-induced spiral break-up likely account for the onset of fibrillation.
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Modeling of diffuse fibrosis suggests alternative fibrillation mechanisms; leaves open restitution's role pending experimental validation.
Tusscher et al. (2007) studied Arrhythmias and sudden cardiac death associated with diffuse fibrosis. Diffuse fibrosis was evaluated on Wave propagation, arrhythmogenesis, and arrhythmia mechanism. Computer modelling demonstrated that diffuse fibrosis slows wave propagation, increases vulnerability to spiral wave formation, and suppresses restitution-induced transition to fibrillation.
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