Key result
Simulated fibrosis at smaller spatial scales lengthened APD, increased APD dispersion, and increased vulnerability to sustained re-entry relative to fibrosis at larger spatial scales.
In a computational model of human atrial tissue, smaller spatial scales of fibrosis increased APD dispersion and vulnerability to re-entry compared to larger scales.
No takes yet. Share an insight, caveat, or question.
May inform fibrosis scale in AF models; leaves open clinical translation and validation.
Richard H. Clayton (2018) studied Atrial fibrillation. Simulated fibrosis at smaller spatial scales vs. Fibrosis at larger spatial scales was evaluated on Dispersion of action potential duration (APD) and vulnerability to re-entry. Simulated fibrosis at smaller spatial scales lengthened APD, increased APD dispersion, and increased vulnerability to sustained re-entry relative to fibrosis at larger spatial scales.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: