Key result
Selective intracoronary hypothermia enters the EURO-ICE trial to evaluate infarct size reduction in STEMI.
Why the study?
Systemic cooling methods have failed to confirm hypothermia's cardioprotective effect against reperfusion injury in humans, prompting the evaluation of selective intracoronary hypothermia during PPCI for STEMI.
Does selective intracoronary hypothermia reduce infarct size in patients with ST-elevation myocardial infarction?
Does selective intracoronary hypothermia reduce infarct size in patients with ST-elevation myocardial infarction?
The EURO-ICE trial is designed to evaluate whether a novel method of selective intracoronary hypothermia during primary PCI can effectively reduce infarct size in patients with STEMI.
EURO-ICE RCT will test selective intracoronary hypothermia during PPCI for infarct size reduction in STEMI; provides first randomized clinical evidence.
In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes 1. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury 2. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS 3. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI 4. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS.
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Farissi et al. (2021) studied this question. Selective intracoronary hypothermia will be evaluated for its effect on infarct size in patients with ST-elevation myocardial infarction in the EURO-ICE trial.
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