Key result
Mild therapeutic hypothermia combined with primary PCI showed non-significant trends toward lower 6-month mortality (25% vs 35%, p=0.71) and improved neurologic outcome (69% vs 47%, p=0.30).
Why the study?
Does mild therapeutic hypothermia combined with primary PCI improve mortality and neurologic outcome in unconscious patients after out-of-hospital cardiac arrest due to STEMI?
Population
33 unconscious patients after out-of-hospital cardiac arrest with ventricular fibrillation as initial rhythm…
Comparison
Mild therapeutic hypothermia initiated… vs Historical control group of 17 consecutive…
Design
Cohort
Follow-up
6 months
Authors
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Should not change practice yet in post-arrest STEMI; hypothesis-generating for mild hypothermia with PCI, needing RCTs.
Observational (n=33)
No
Does mild therapeutic hypothermia combined with primary PCI improve mortality and neurologic outcome in unconscious patients after out-of-hospital cardiac arrest due to STEMI?
Absolute Event Rate: 25% vs 35%
p-value: p=0.71
Mild therapeutic hypothermia combined with primary PCI is feasible and safe in unconscious patients resuscitated from out-of-hospital cardiac arrest due to STEMI, without delaying door-to-balloon times.
Wolfrum et al. (2008) conducted an observational in Out-of-hospital cardiac arrest due to acute ST-segment elevation myocardial infarction (n=33). Mild therapeutic hypothermia (MTH) with primary PCI vs. Primary PCI without MTH (historical control) was evaluated on Mortality after 6 months (p=0.71). Mild therapeutic hypothermia combined with primary PCI showed non-significant trends toward lower 6-month mortality (25% vs 35%, p=0.71) and improved neurologic outcome (69% vs 47%, p=0.30).
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