Key result
Altered closed-state inactivation in the Nav domain IV voltage sensor underlies sodium channelopathies.
Closed-state inactivation (CSI) is highlighted as a key biophysical mechanism to focus on for understanding the pathophysiology of sodium channelopathies.
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CSI as therapeutic target in channelopathies; leaves open clinical translation of domain IV findings.
s, and altered CSI can be an underlying primary biophysical defect of sodium channelopathies. Therefore, CSI should receive focus in order to clarify the pathophysiology of sodium channelopathies.
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Nakajima et al. (2019) studied this question. Altered closed-state inactivation linked to the voltage sensor module in Nav domain IV represents a primary biophysical defect underlying sodium channelopathies.
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