Key result
Treadmill exercise testing induced hypotension and syncope or pre-syncope in 5 patients without structural heart disease, demonstrating a new condition of exercise-induced neurally mediated syncope.
Case Report (n=5)
Reports a condition of exercise-induced neurally mediated (vasodepressor) syncope in patients without appreciable structural cardiac abnormalities.
May warrant evaluation for neurally mediated syncope in unexplained exercise-related events without structural disease; leaves open need for prospective validation.
Five cases of exercise induced pure vasodepressor syncope in patients without significant structural heart disease are reported. Hypotension and symptoms of syncope or pre-syncope were induced by treadmill exercise testing and in each case limited exercise performance. Evidence of inappropriate peripheral vasodilation, probably as a consequence of ventricular mechanoreceptor stimulation, was shown in all five patients. Head up tilt testing resulted in hypotension in four patients and isoprenaline infusion in the supine position resulted in hypotension in the fifth. These patients had a new condition of exercise induced neurally mediated (vasodepressor) syncope without appreciable structural cardiac abnormalities.
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Sneddon et al. (1994) conducted a case report in Exercise induced vasodepressor syncope (n=5). Treadmill exercise testing was evaluated on Hypotension and symptoms of syncope or pre-syncope. Treadmill exercise testing induced hypotension and syncope or pre-syncope in 5 patients without structural heart disease, demonstrating a new condition of exercise-induced neurally mediated syncope.