Infusion of a vasodilator in a heart-transplant recipient provoked a vasodepressor reaction leading to vasovagal syncope.
Case Report (n=1)
Does infusion of a vasodilator cause vasovagal syncope in a heart-transplant recipient?
This case report highlights the occurrence of paradoxical vasodepressor reactions (vasovagal syncope) following vasodilator infusion in a denervated heart-transplant recipient.
HYPOTENSIVE states are well known to activate the sympathetic nervous system, leading to reflex vasoconstriction and tachycardia.1 Hypovolemic hypotension, however, can be accompanied by paradoxical withdrawal of sympathetic drive, leading to vasodilation and bradycardia — responses that, in turn, exacerbate the decrease in blood pressure.2 3 4 5 In humans, hypotension with an inappropriately normal or frankly decreased heart rate has been observed during hemorrhagic shock,6 after the infusion of vasodilators,7 and most recently, in response to the infusion of isoproterenol during the upright-tilt test, which is used to provoke syncope.8 , 9 The current belief is that this type of vasodepressor reaction is a . . .
Scherrer et al. (Thu,) conducted a case report in Vasovagal syncope in a heart-transplant recipient (n=1). Vasodilator infusion was evaluated on Vasovagal syncope. Infusion of a vasodilator in a heart-transplant recipient provoked a vasodepressor reaction leading to vasovagal syncope.