Key result
Female rats show greater fibrosis reversibility but less functional anti-remodeling than males after pressure unloading.
Why the study?
The role of sex on pressure unloading-induced reverse and anti-remodeling remained to be assessed.
Does sex influence the reverse and anti-remodeling effect of pressure unloading therapy in a rat model of aortic banding?
Does sex influence the reverse and anti-remodeling effect of pressure unloading therapy in a rat model of aortic banding?
This study provides the first evidence of sex-specific differences in cardiac reverse remodeling following pressure unloading in a rat model, with females showing greater molecular reversibility and males showing greater functional anti-remodeling.
Hypothesis-generating for sex-specific reverse remodeling after pressure unloading; clinical translation requires prospective human studies.
The present study is the first to assess the role of sex on pressure unloading-induced reverse and anti-remodeling in a rat model of aortic banding and debanding. Our data indicate that female sex is associated with a greater reversibility of fibrosis, fetal gene expression, and proteomic alterations compared with males. Nevertheless, pressure unloading exposes more anti-remodeling effect on the functional level in males, which is attributed to the more rapid functional deterioration in aortic-banded animals.
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Ruppert et al. (2022) studied Aortic banding and debanding. Pressure unloading therapy vs. Male vs Female was evaluated on Reverse and anti-remodeling effect. Female sex in a rat model of pressure unloading was associated with greater reversibility of fibrosis and molecular alterations compared with males, though males showed more functional anti-remodeling.
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