Key result
Single-cell dual-omics reveals previously unrecognized cardiac fibroblast subpopulations in adult murine hearts.
Why the study?
The precise cellular identity and molecular features of non-myocytes in the mammalian heart at a single-cell level remained elusive.
Single-cell dual-omics mapping of the adult murine heart reveals extensive heterogeneity and novel functional subpopulations of cardiac fibroblasts.
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Offers no immediate clinical guidance; leaves open therapeutic targeting of novel fibroblast subpopulations in human cardiac disease.
Wang et al. (2021) studied Healthy and diseased murine hearts. Single-cell dual-omics was evaluated on Transcriptomic and epigenomic diversity of cardiac non-myocytes. Single-cell dual-omics characterized the transcriptomic and epigenomic diversity of cardiac non-myocytes in adult murine hearts, revealing previously unrecognized fibroblast subpopulations.
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