Why the study?
A comprehensive understanding of the interactive community of interstitial cell types in the heart—including fibroblast, vascular, and immune cells—is lacking.
Population
>30,000 single cells from murine hearts at days 3 and 7 post-sham or MI surgery
Comparison
MI surgery vs sham surgery
Design
Single-cell RNA-sequencing study in mice
Authors
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Does not yet inform post-MI management; leaves open functional roles of novel fibroblast subtypes in human repair.
Single-cell RNA sequencing of the non-cardiomyocyte fraction in murine hearts post-MI reveals novel fibroblast and myofibroblast subtypes, highlighting complex cellular dynamics during cardiac injury and repair.
Farbehi et al. (2019) studied this question.
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