Key result
Autonomous cortisol secretion in primary aldosteronism is linked to ~25-fold higher type 2 diabetes prevalence.
Why the study?
The relationship between autonomous cortisol secretion and glucose metabolism in primary aldosteronism had not been investigated.
Does autonomous cortisol secretion increase the risk of impaired glucose metabolism and type 2 diabetes in patients with primary aldosteronism?
Population
161 newly diagnosed patients with primary aldosteronism and matched population-based controls
Comparison
Cortisol cosecretion status vs normal cortisol secretion and matched controls
Design
Matched observational cohort study
Authors
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Autonomous cortisol secretion may warrant diabetes screening in primary aldosteronism; leaves open causality and need for prospective trials.
Observational (n=644)
Does autonomous cortisol secretion increase the risk of impaired glucose metabolism and type 2 diabetes in patients with primary aldosteronism?
Absolute Event Rate: 20% vs 0.8%
p-value: p=< 0.0001
Autonomous cortisol secretion is common in primary aldosteronism and is significantly associated with impaired glucose metabolism and a higher risk of type 2 diabetes.
Gerards et al. (2019) conducted an observational in Primary aldosteronism (n=644). Autonomous cortisol secretion (pathological DST) vs. Normal DST and matched population controls was evaluated on Diagnosis of type 2 diabetes mellitus (p=< 0.0001). Autonomous cortisol secretion in primary aldosteronism is associated with a higher prevalence of type 2 diabetes compared to patients with normal cortisol suppression (20% vs 0.8%, P<0.0001).
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