Key result
Autonomous cortisol secretion in primary aldosteronism links to worse arterial stiffness and greater vascular fibrosis.
Why the study?
Autonomous cortisol secretion is common in primary aldosteronism and potentially linked to poor outcomes, but its association with vascular remodeling was unclear.
Is autonomous cortisol secretion associated with worse arterial stiffness and vascular fibrosis in patients with primary aldosteronism?
Cross-Sectional (n=436)
Is autonomous cortisol secretion associated with worse arterial stiffness and vascular fibrosis in patients with primary aldosteronism?
Effect estimate: β 235.745 (95% CI 59.602-411.888)
p-value: p=0.010
In patients with primary aldosteronism, autonomous cortisol secretion is associated with increased arterial stiffness and vascular fibrosis, which improves after targeted treatment.
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May identify higher-risk primary aldosteronism subsets; leaves open causal role in vascular stiffness.
Tsai et al. (2022) conducted a cross-sectional in Primary aldosteronism (n=436). Autonomous cortisol secretion (ACS) vs. Without ACS was evaluated on Baseline mean brachial-ankle pulse wave velocity (baPWV) (β 235.745, 95% CI 59.602-411.888, p=0.010). Autonomous cortisol secretion in primary aldosteronism patients was associated with worse baseline arterial stiffness (β: 235.745; 95% CI 59.602-411.888; P=0.010) and greater vascular fibrosis.
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