January 1, 2022Therapeutic Advances in Chronic DiseaseOpen Access

Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism

View Full Paper

Ask AI

Bookmark

Why the study?

The impact of diabetes mellitus on baseline and post-treatment arterial stiffness in patients with primary aldosteronism was unknown.

Does the presence of diabetes mellitus impair the post-treatment recovery of arterial stiffness in patients with primary aldosteronism?

Population

1071 PA patients (177 with diabetes and 894 without)

Comparison

Diabetes mellitus vs no diabetes mellitus

Design

Prospective cohort study with propensity score matching

Follow-up

1 year

Authors

CTCheng‐Hsuan TsaiBrigham and Women's Hospital XWXue-Ming WuJishou University CLChe‐Wei LiaoNational Taiwan University

Discussion

Member takes

Implication

Diabetes may blunt arterial stiffness recovery after PA treatment; hypothesis-generating for glycemic optimization effects.

Structured PICO

Does the presence of diabetes mellitus impair the post-treatment recovery of arterial stiffness in patients with primary aldosteronism?

Population

1,071 prospectively enrolled patients with primary aldosteronism (PA), including 177 with diabetes mellitus and 894 without. After propensity score matching, 144 patients with diabetes and 320 without diabetes were analyzed. Mean age ~56, ~47% male, Taiwan-based cohort.

Intervention

Presence of diabetes mellitus in patients undergoing PA-specific treatment (mineralocorticoid receptor antagonists or adrenalectomy) for 1 year

Comparator

Absence of diabetes mellitus in patients undergoing PA-specific treatment (mineralocorticoid receptor antagonists or adrenalectomy) for 1 year

Outcome

Brachial-ankle pulse wave velocity (baPWV) at baseline and 1 year after PA-specific treatmentsurrogate

In patients with primary aldosteronism, concurrent diabetes mellitus is associated with worse baseline arterial stiffness and blunted vascular recovery after 1 year of targeted therapy.

Cite This Study

Tsai et al. (2022) studied this question.

synapsesocial.com/papers/6a887b59b98a632b5e4fe280 https://doi.org/10.1177/20406223211066727

View Full Paper

Ask AI

Bookmark

Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider