Key result
Autonomous cortisol secretion (midnight cortisol ≥7.4 μg/dl) in primary aldosteronism was associated with higher prevalence of cardiovascular events (OR 7.0; 95% CI 1.8-30.6; P=0.006).
Why the study?
Does autonomous cortisol secretion increase the prevalence of cardiovascular events in patients with primary aldosteronism?
Cross-Sectional (n=76)
No
Does autonomous cortisol secretion increase the prevalence of cardiovascular events in patients with primary aldosteronism?
Odds Ratio: 7 (95% CI 1.8–30.6)
p-value: p=0.006
Autonomous cortisol secretion in patients with primary aldosteronism is associated with a significantly increased risk of cardiovascular events.
No takes yet. Share an insight, caveat, or question.
May warrant cortisol co-secretion assessment in PA; leaves open causal links and need for prospective outcome trials.
Nakajima et al. (2011) conducted a cross-sectional in Primary aldosteronism (n=76). Autonomous cortisol secretion vs. Without autonomous cortisol secretion was evaluated on Cardiovascular events (CVE) (OR 7.0, 95% CI 1.8-30.6, p=0.006). Autonomous cortisol secretion (midnight cortisol ≥7.4 μg/dl) in primary aldosteronism was associated with higher prevalence of cardiovascular events (OR 7.0; 95% CI 1.8-30.6; P=0.006).
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