Key result
Primary aldosteronism was significantly associated with an increased risk of stroke (RR 2.03) and coronary artery disease (RR 1.67) compared to essential hypertension.
Why the study?
It was unclear whether increased cardiovascular risk and the incidence of cerebrovascular events in hypertensive patients were related to primary aldosteronism.
Does primary aldosteronism increase the risk of cardiovascular and cerebrovascular events compared to essential hypertension?
Meta-Analysis (n=56,830)
Does primary aldosteronism increase the risk of cardiovascular and cerebrovascular events compared to essential hypertension?
Relative Risk: 2.03 (95% CI 1.71–2.39)
Primary aldosteronism is associated with a significantly higher risk of stroke, coronary artery disease, and left ventricular hypertrophy compared to essential hypertension, highlighting the need for periodic cardiovascular risk assessment in these patients.
No takes yet. Share an insight, caveat, or question.
Supports periodic cardiovascular risk assessment in primary aldosteronism; extends prior evidence via meta-analysis.
Wu et al. (2019) conducted a meta-analysis in Primary aldosteronism (n=56,830). Primary aldosteronism vs. Essential hypertension was evaluated on Stroke (RR 2.03, 95% CI 1.71-2.39). Primary aldosteronism was significantly associated with an increased risk of stroke (RR 2.03) and coronary artery disease (RR 1.67) compared to essential hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: