Key result
Antihypertensive combinations including lisinopril, losartan, and valsartan linked to lower BP and improved arterial stiffness.
Why the study?
Hypertension is a major contributor to global morbidity and mortality, but the effects of different antihypertensive combinations on blood pressure, arterial stiffness, and peripheral resistance needed investigation.
Do different combinations of antihypertensive therapy improve blood pressure and arterial stiffness in patients with essential hypertension?
Observational
Do different combinations of antihypertensive therapy improve blood pressure and arterial stiffness in patients with essential hypertension?
Various combinations of ACE inhibitors or ARBs with hydrochlorothiazide and/or amlodipine are equally effective in reducing blood pressure and improving arterial stiffness in essential hypertension.
These combinations may aid BP and stiffness control; leaves open optimal regimen selection in randomized trials.
INTRODUCTION: Hypertension is significantly contributing to global mortality and morbidity and has been identified as the most important modifiable risk factor for early development of cardiovascular diseases (CVD). AIM: The aim of this study was to investigate the efficacy of different combinations of antihypertensive therapy on blood pressure, arterial stiffness and peripheral resistance in patients with essential hypertension using the brachial oscillometric ambulatory blood pressure monitor. METHODS: follow-up). Brachial oscillometric ambulatory blood pressure monitor was used for measuring systolic (SBP), diastolic (DBP), pulse pressure (PP), pulse wave velocity (PWV) and peripheral resistance (PR). RESULTS: follow-up. Peripheral resistance significantly decreased only in group C (p=0.011), group D (p=0.009) and group F (p=0.027). CONCLUSION: These data suggest that lisinopril/lisinopril + hydrochlorothiazide, losartan/losartan + hydrochlorothiazide and valsartan/valsartan + hydrochlorothiazide alone or in combination with amlodipine are equally effective and well tolerated for the reduction of both systolic and diastolic blood pressure and improve arterial stiffness in patients with essential hypertension.
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Jatić et al. (2019) conducted an observational in essential hypertension. Antihypertensive combinations (lisinopril, losartan, valsartan, hydrochlorothiazide, amlodipine) vs. Different combinations was evaluated on blood pressure, arterial stiffness and peripheral resistance. Antihypertensive combinations including lisinopril, losartan, and valsartan effectively reduced blood pressure and improved arterial stiffness, with peripheral resistance decreasing in specific groups (p=0.011, p=0.009, p=0.027).
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