Key result
Losartan significantly decreased arterial wave reflection (P<.0001) and aortic pulse pressure (P<.001) compared to hydrochlorothiazide, despite similar reductions in brachial blood pressure.
Why the study?
Does losartan improve arterial stiffness compared to hydrochlorothiazide in untreated hypertensive patients?
RCT (n=11)
Single-blind
Crossover
Does losartan improve arterial stiffness compared to hydrochlorothiazide in untreated hypertensive patients?
p-value: p=<.0001
Losartan reduces aortic stiffness and arterial wave reflection independently of blood pressure reduction when compared to hydrochlorothiazide in hypertensive patients.
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Losartan may be preferred over hydrochlorothiazide to improve central hemodynamics in hypertension; confirms ARB effects on arterial stiffness beyond brachial BP reduction.
Azra Mahmud (2002) conducted an RCT in Hypertension (n=11). Losartan vs. Hydrochlorothiazide (12.5 mg/day) was evaluated on Blood pressure and arterial stiffness (arterial wave reflection) (p=<.0001). Losartan significantly decreased arterial wave reflection (P<.0001) and aortic pulse pressure (P<.001) compared to hydrochlorothiazide, despite similar reductions in brachial blood pressure.
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