Losartan significantly decreased arterial wave reflection (P<.0001) and aortic pulse pressure (P<.001) compared to hydrochlorothiazide, despite similar reductions in brachial blood pressure.
RCT (n=11)
Single-blind
Crossover
Does losartan improve arterial stiffness compared to hydrochlorothiazide in untreated hypertensive patients?
Losartan reduces aortic stiffness and arterial wave reflection independently of blood pressure reduction when compared to hydrochlorothiazide in hypertensive patients.
p-value: p=<.0001
We compared the effect of losartan (50 mg/day) to hydrochlorthiazide (12.5 mg/day) on blood pressure (BP) and arterial stiffness in 11 untreated hypertensive patients aged 47 to 69 years in a 4-week single blind randomized crossover study with an intervening 4-week washout period. Both drugs produced a significant (P <.001) and similar decrease in brachial BP. Only losartan induced a significant decrease in arterial wave reflection (P <.0001), with a preferential reduction in aortic (P <.001) compared to brachial pulse pressure. Losartan also significantly increased pulse pressure amplification and reduced pulse wave velocity. These results suggest that an AT(1) receptor antagonist induces a BP independent decrease in aortic stiffness and arterial wave reflection.
Azra Mahmud (Sun,) conducted a rct in Hypertension (n=11). Losartan vs. Hydrochlorothiazide (12.5 mg/day) was evaluated on Blood pressure and arterial stiffness (arterial wave reflection) (p=<.0001). Losartan significantly decreased arterial wave reflection (P<.0001) and aortic pulse pressure (P<.001) compared to hydrochlorothiazide, despite similar reductions in brachial blood pressure.