Why the study?
Does losartan reduce resistance artery stiffness compared to atenolol in untreated mild essential hypertensive patients?
Population
17 untreated mild essential hypertensive patients, mean age 47+/-2 years, 75% male
Comparison
Losartan treatment for one year vs Atenolol treatment for one year
Design
RCT, randomly assigned, double-blind fashion
Follow-up
one year
Authors
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Losartan may confer vascular structural benefits beyond BP lowering in mild hypertension; extends RCT evidence of ARBs outperforming beta-blockers on resistance artery remodeling.
Does losartan reduce resistance artery stiffness compared to atenolol in untreated mild essential hypertensive patients?
Losartan, but not atenolol, reduces stiffness and structural alterations of subcutaneous resistance arteries in patients with mild essential hypertension.
Park et al. (2000) studied this question.
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