December 1, 1994American Journal of Hypertension

Hemodynamic and Humoral Effects of the Angiotensin II Antagonist Losartan in Essential Hypertension

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Why the study?

Does losartan reduce blood pressure and alter humoral factors in patients with essential hypertension?

Population

15 patients with essential hypertension and a diastolic blood pressure between 95 and 115 mm Hg after 2…

Design

Cohort

Follow-up

12 months

Authors

EGEhud GrossmanPreventive Cardiology EPEdna PelegTel Aviv University JCJudith A. CarrollUniversity of Toledo Medical Center

Discussion

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Implication

Losartan was associated with short-term MAP reduction in this cohort; leaves open effects on humoral factors and clinical outcomes pending randomized trials.

Structured PICO

Does losartan reduce blood pressure and alter humoral factors in patients with essential hypertension?

Population

15 patients (12 men, 3 women; mean age, 46 +/- 2 years) with essential hypertension and a diastolic blood pressure (DBP) between 95 and 115 mm Hg after 2 weeks of placebo.

Intervention

Losartan 50 mg once daily for 1 month, with subsequent addition of hydrochlorothiazide (6.25 to 12.5 mg daily) and nifedipine (30 to 60 mg daily) as needed for up to 12 months.

Outcome

Change in mean arterial pressure, heart rate, and plasma levels of creatinine, potassium, uric acid, cholesterol, renin activity (PRA), aldosterone, and norepinephrine at 1 and 12 months.surrogate

Losartan effectively lowers blood pressure and favorably alters the renin-angiotensin-aldosterone system in patients with essential hypertension.

Cite This Study

Grossman et al. (1994) studied this question.

synapsesocial.com/papers/6a82b677ca0a238f9c75b0ae https://doi.org/10.1093/ajh/7.12.1041

Topics

Hypertension management

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Implication

Losartan was associated with short-term MAP reduction in this cohort; leaves open effects on humoral factors and clinical outcomes pending randomized trials.

Hemodynamic and Humoral Effects of the Angiotensin II Antagonist Losartan in Essential Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Hemodynamic and Humoral Effects of the Angiotensin II Antagonist Losartan in Essential Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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