Why the study?
Does losartan combined with hydrochlorothiazide compared to losartan monotherapy improve blood pressure, central hemodynamics, and microcirculation in patients with mild to moderate essential hypertension?
Population
40 patients with mild to moderate essential hypertension
Comparison
Losartan 50 mg in combination with… vs Losartan 50 mg monotherapy
Design
RCT, randomly allocated
Follow-up
8 weeks
Authors
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Both losartan regimens reduce BP via lower vascular resistance in mild-moderate hypertension; confirms efficacy and extends RCT evidence to microcirculation.
Does losartan combined with hydrochlorothiazide compared to losartan monotherapy improve blood pressure, central hemodynamics, and microcirculation in patients with mild to moderate essential hypertension?
Losartan and its combination with hydrochlorothiazide effectively lower blood pressure through reduced peripheral vascular resistance and improve microcirculation in mild to moderate essential hypertension.
Подзолков et al. (2003) studied this question.
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