Why the study?
Does losartan added to hydrochlorothiazide reduce blood pressure in hypertensive patients not adequately controlled by hydrochlorothiazide monotherapy?
Population
304 hypertensive patients with trough sitting diastolic pressure between 93 and 120 mm Hg despite a 4-week…
Comparison
Losartan 25 mg, 50 mg, or 100 mg once daily… vs Matching placebo once daily added to 25 mg…
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
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Supports losartan addition to hydrochlorothiazide for better control in uncontrolled hypertension; confirms additive efficacy in this RCT.
Does losartan added to hydrochlorothiazide reduce blood pressure in hypertensive patients not adequately controlled by hydrochlorothiazide monotherapy?
Adding losartan to hydrochlorothiazide provides significant, dose-dependent blood pressure reductions and is well tolerated in patients with hypertension uncontrolled by hydrochlorothiazide alone.
Soffer et al. (1995) studied this question.
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